Our work focuses on understanding the principles underlying cell-fate decisions and, in turn, utilizing these to rationally target fate-regulating circuits for therapeutic benefit. To achieve this we couple mathematical methods with ‘wet-lab’ experiments to identify fundamental regulatory principles governing fate selection in viruses.
HIV and CMV as model systems
Viral pathogens are attractive models for fate selection because pathogenicity generates inherent fitness trade-offs (e.g. pathogens must balance transmission against virulence). To overcome these inherent trade-offs, one strategy viral pathogens have evolved is ‘bet-hedging’ between active and latent states, reviewed in (Weinberger and Weinberger, 2013). Since viruses are genetically constrained—selecting for minimalist regulatory circuits—they are ideal for identifying core regulatory principles underlying biological bet-hedging decisions.
Much of our work focuses on exploring the fundamental fate selection circuitry of two different viruses: HIV and the human herpesvirus cytomegalovirus (CMV). The following pages (linked left) expand more deeply on our current projects.